The pair are said to have arrived in Rome for the wedding of their friend Misha Nonoo, who is due to tie the knot on Friday (20.09.19).
A royal correspondent for The Sun reported on Twitter that sources spotted the couple touching down in the Italian capital.
Meghan collaborated with Misha, who is marrying US businessman Michael Hess, on the launch of her new capsule clothing line.
Emily wrote: "Eagle Italian eyes tell me that Harry and Meghan were spotted arriving in Rome today for tomorrow's wedding of the Duchess' best mate Misha Nonoo to US oil tycoon Michael Hess."
Eye witnesses reported that Meghan and Harry didn't have Archie with them, which suggests they are looking forward to some baby-free time ahead of their royal tour of Africa, which kicks off on Monday.
The Sussexes are due to fly to Cape Town, after which Harry will travel to Botswana, Angola and Malawi before re-uniting with his wife and son in South Africa's largest city, Johannesburg.
Meghan gave birth to her first child in May and the Sussexes have since kept many details of the tot secret.
The couple held a private christening for their son away from the eyes of the public, with the exception of a few official photos shared to their Instagram account.
Unlike other royals in the past, the Duke and Duchess have also kept the identity of Archie's godparents a secret
The names of godparents are usually revealed after the christening, but Harry and Meghan are yet to announce theirs.
Eagle Italian eyes tell me that Harry and Meghan were spotted arriving in Rome today.
According to royal expert Katie Nicholl, Meghan dropped a clue about one of her son's godparents during a recent royal outing.
The Duchess returned to work from maternity leave this month with the launch of her Smart Set clothing collection for the charity Smart Works, which supports unemployed women through interview coaching and personalised styling.
And royal writer Katie claimed that Archie's godmother, Isabel May, was at the event, telling Entertainment Tonight: "I was there at the launch and spotted in the audience Isabel May, who is in fact Archie’s godmother, although that's been kept very, very quiet.
"She's a great friend of the Duchess and, of course, she would have known all about this launch."
It followed reports earlier this year suggesting that Isabel was a godparent, with a source telling Mail On Sunday: "Izzy is one of Meghan's dearest and closest friends and she values her friendship so very much. Izzy keeps their relationship really quiet and very much under the radar.
"The time they spend together is private. She helped Meghan adjust to life in London when she moved here from Canada. Meghan relied on her a lot.
"They are just like any two young female friends. They totally support one another and enjoy lots of social activities together."
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