Carol, who has just returned from a holiday in France, said: "I'm not sure it's going to make much difference."
But fans of the show were horrified by her "dangerous" comments.
Taking to Twitter one wrote: "ITV should take Loose Woman off the air this second.
"Millions watching this and we have Carol spouting her dangerous views without a shred of credibility."
While another slammed the star, he said: "Carol McGiffin on Loose Women now to tell us that she doesn't think lockdown will make any difference, despite all evidence to the contrary.
"Staggering that these imbeciles get to spread dangerous misinformation like this."
A third added: "Why did Carol laugh at the process of washing your hands. Ridiculous attitude people are dying."
Carol admitted that she was actually in two minds about coming back to the UK.
Calling out all the panic buyers on their behaviour, she said: "Mad people over here think they're never going to go out of the house again."
You're making me anxious just doing that.
And to fellow panellist Nadia Sawalha, who had been using antibacterial wipes, Carol said: "You're making me anxious just doing that."
Meanwhile, Stacey Solomon has been at home self-isolating with her family this week and is refused to shave her legs until she returns to the show - which was today (March 19).
While sitting on her bed with a cuppa Stacey posted a story on her Instagram, she wrote: "I know what you're thinking... 'if she has to self isolate maybe she'll find some time to shave those abominable snowman legs.'
"I might maybe, probably not."
Who knows if she did shave?
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