Choking back tears, Holly sniffed and declared: "I can't bear it."
The clip featured images of Harry and Meghan's wedding and the couple introducing son Archie to the world.
It also included Harry's speech at the Sentebale event in London, where he admitted he had "no other option" but to step down as a senior member of the royal family.
Holly admitted she "felt emotional" watching the clips.
She said: "When I watched him speaking it actually made me feel quite emotional. I felt it."
Holly added: "You could feel it was a choice they made out of their hands. You felt it was a choice they made to survive a little bit."
When I watched him speaking it actually made me feel quite emotional. I felt it.
However, viewers were left a little perplexed at Holly's emotional reaction to the clips.
It looked like Holly had tears in her eyes at the end of that #ThisMorning
— CD13 (@CD13092) January 20, 2020
Another said: "Why the hell was Holly crying? Can't believe people are upset and even offended by their decisions. I am happy for them and really hope it all works out."
Others, however, said This Morning had likened Harry and Meghan's departure from the royal family to an eviction from a reality TV show by airing their best bits.
It was like ; ‘Harry, Meghan, you’ve been voted out , these are your best bits!’ 😂😂😂
We don’t caaaaaaare! #Royals
— Gary (@thegaaary) January 20, 2020
Why did #ThisMorning need to show a best bits montage of Harry and Meghan? They weren't evicted from a reality show, you know!
— J🇬🇧🇳🇬🦁❤ (@MissLionHeart) January 20, 2020
Others admitted they were crying too, but their tears were tears of laughter.
Harry and Meghan: Their best bits 🤣🤣🤣🤣 #ThisMorning
— Baroness Beckie (@Beckie_Miller_) January 20, 2020
Viewers were last week left scratching their heads when Holly came to work dressed in what looked like school uniform.
Did you find the best bits moving? Tell us on our Facebook page @EntertainmentDailyFix.